To HENDY who has loaded the comments of this piece with anti-Ivermectin studies, we have sent your links to medical experts who are reviewing them and we will reply after the examination is complete.
You have provided an excessive amount of medical documentation so it is going to take us some time to respond.
Hi Michael, these are not "anti-ivermectin" studies. That's a childish way to frame it. These are actually just a few of the studies. I can't even keep track of them myself. I can keep sending more and more if you like but I think you get the point.
I've taken IVM myself and did a curiosity search and started to see extremely alarming results in these studies. Needless to say, I don't take it anymore.
I definitely believe your concerns are valid and need to be looked into.
There are many studies where the IVM dosage was doubled, tripled and MORE - and then the conclude "Oh! it's unsafe!" - well, of course it's unsafe at unsafe levels.
Many of the studies you are referencing are in animals - which is odd at this point because for decades BILLIONS of humans have taken it, so we should really stay focused on results in humans as there is plenty to look at.
And, of course, Big Pharma has a MOTIVE to fund studies that discredit this drug because it is cheap and has no patent on it.
Nevertheless, I have sent your concerns to medical doctors we work with and await their responses. It's worthy of inquiry, for sure.
In a paper called ‘Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations’ a case study is examined by which a 13 year old boy was sent to the hospital in a coma after just one ivermectin pill.
Retinopathy associated with ivermectin toxicosis in five cats’
--
“Five domestic shorthair farm cats … sudden onset of tremors, obtundation, blindness, and dilated pupils. Less than 12 hours earlier, the owner had attempted to treat the cats for a suspected ear mite (Otodectes cynotis) infestation by aural administration of a dose of an ivermectin paste intended for oral administration to horses (approx 22 mg/cat; half of the dose was administered into each ear canal).”
Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases,’ researcher Twum-Danso goes through passive reported serious adverse events for Ivermectin.
“For more than half of the cases (n = 118; 57%), the SAE occurred following their first exposure to ivermectin. The mean time from ivermectin treatment to onset of symptoms was 2.2 days (95% CI: 1.8, 2.5)”
Of the cases with altered mental status when first encountered by a clinician (n = 106), 52 were confused, obtunded or lethargic while 16 presented with stupor and 38 presented in frank coma.
In a study called ‘Effect of ivermectin on male fertility and its interaction with P-glycoprotein inhibitor (verapamil) in rats’ by El-Nahas & El-Ashmawy
“We observed significant reduction in the sperm counts and sperm motility of the patients tested. On the morphology there was significant increase in the number of abnormal sperm cells. This took the forms of two heads, double tails, white (albino) sperms and extraordinarily large heads. It is suspected that the above alterations in the already determined parameters of the patients’ sperm cells could only have occurred as a result of their treatment with ivermectin.”
Ivermectin was touted as a perfectly safe drug, and now we see all the studies that it causes infertility and a long list of alarming health problems including blindness and paralysis.
Where are "all the studies" you refer to with no citation?
Ivermectin has been used for decades, taken by BILLIONS of people and won the Nobel Prize for ending 2 endemic disease in humans. Please post references to the "long list of alarming health problems" you claim it is connected to
I don't think I can post links in the comments here. I think it would get flagged as spam. If you want the full download, I can start popping it in here.
I thought it was super safe and very effective and this does not appear to be the case.
Yes you certainly can post links in the comments. I do it all the time on Substack.
Full disclosure - I and my family have taken Ivermectin multiple times and it has worked very well, safe and effective, every time. I am open to reviewing documentation.
1. “Effects of ivermectin on spermatocyte chromosomes: Structural aberrations: Cytological analysis of diakinesis-metaphase I spermatocytes of the treated samples revealed significant increase in chromosome aberrations over the control values.”
“Analysis of the treated samples revealed significant increase in meiotic aberrations, 33.83% vs 5.8% for the control (P < 0.001)… These findings supports the mutagenicity of IVM”
2. “In addition, the numbers of binucleated lymphocytes showed dose dependent decrease than control. These results revealed that the drug has a cytotoxic effect on the number of cell divisions. As the micronuclei are small chromatin-containing bodies arising from chromosome fragmentation by breaks or deletion, the results of MN [micronuclei] formation confirmed our results of chromosomal aberrations indicating the clastogenic effects of ivermectin.”
3. “IVM induced high level of chromosome aberrations in somatic cells, as it is ascertained by chromosome aberration assay and micronuclei production in bone marrow cells. This study revealed high clastogenic and genotoxic potential of IVM on mice”
5. “The results indicate that IVM can induce DNA double-strand breaks in HeLa cells, and the degree of double-strand break is dependent on the concentration of IVM.”
“Ivermectin has significant ability to induce DNA oxidative damage and enhance autophagy in HeLa cells”
“As expected, we found that IVM can induce oxidative double-stranded damage in HeLa cells, indicating that IVM has potential genotoxicity to human health.”
“We conclude that IVM produces genotoxicity and cytotoxicity by inducing DNA damage and AMPK/mTOR-mediated autophagy, thereby posing a potential risk to human health.”
6. “The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations”
“It was observed a dose-dependence in the frequency of MN [Micronuclei] in T. pallida considering the highest concentrations (11.42, 22.84 and 45.68 × 10−5 mM) differing statistically (p ≤ 0.05) from the negative control, evidencing a genotoxic effect of IVM”
“The results observed in D. melanogaster and T. pallida showed that IVM can increase the damage in the genetic material, leading to genetic instability.”
“Findings showed an increase in the frequency of micronuclei in T. pallida treated with 11.42, 22.84 and 45.68 x 10 −5 mM of IVM. We conclude that chronic exposure to IVM is directly associated with events resulting from genetic instability (genotoxicity and carcinogenicity).”
She definitely posted them, and I can’t wait to hear your response! I quickly reviewed them, and I’m concerned by what I read. However, I don’t fully understand what I read, so hopefully your response will help me understand. As I said, it was a quick review, and I know with anything too much of even a “good thing” can be harmful and or deadly, and too little can also be problematic. So comparing the dosage of Ivermectin given to the mice compared to humans is something that I wasn’t able to determine because I don’t have the scientific training. Also, what were the health of the mice in the studies? How long had these mice lived caged in a stressful environment? Were they given a complete bill of health prior to the experiment? I hope you can clarify that for me. Also, I always want to know about who conducted the study, and were there any conflicts of interest such as any profit motives, fear motives, and job security motives? Clearly, Hendy was well prepared for your request for information. I hope your response will be able to either validate her information or discredit it . Either way, I just want the truth because my family and I have been using it to recover from illnesses, vaccine injuries, and to maintain health. Thanks 🙏 Michael
We have medical professionals taking a look at the studies referenced.
I have personally taken Ivermectin numerous times as have my parents who are both over 70 years of age. It worked remarkably when we had COVID. We supported it with an intense supplementation protocol as well.
My mother is extremely sensitive to all medicines and she had no negative reaction to it, only positive.
None of this is meant as medical advice, I am not a doctor.
My overall understanding of the literature is that there are very minimal risks to taking Ivermectin. But we are having medical professionals review what's been posted here and we will respond. The earliest we will be able to respond is sometime next week.
Like your mother, I’m extremely sensitive to drugs, and I’ve had many bad experiences from them including life threatening with Vioxx and an Ace Inhibitor. I got Ivermectin early on, and I used it prophylactically as well as when I finally did get Covid. The only reaction I had was with my eyes. It was actually an amazing experience. I had injured my eyes from playing a game online that had flashing magenta colored gems that would pop on the screen. After playing it for a couple of weeks, I started seeing flashing lights, and I thought I was having a stroke. But I wasn’t having a stroke, so I went to an eye doctor who said that my retinas weren’t detaching. But no solutions were given for the debilitating flashing lights that prevented me from being able to drive at sunset or nighttime. It was very stressful because it was constant even in my home at sunset and nighttime, and it went on for months until I took Ivermectin. The first thing I noticed was that my eyes hurt, but I didn’t panic because I knew that it prevented River Blindness. So I just assumed that it was helping my eyes.
After the first time I used Ivermectin, the flashing in my right eye disappeared!! I was amazed and so happy!! Then the second time I used it, the left eye hurt, and then the flashing lights were gone. So for me, Ivermectin helped my eyes and eliminated a very debilitating condition which I was so grateful for!! So I’m a huge fan of Ivermectin; but regardless of my support for it, we need the facts and the truth. So I’m glad to know that you are having medical professionals reviewing the studies, and I look forward to hearing what they have to say when that time comes. Thank you 🙏 Michael for your response and your efforts in finding the truth. Bambi
But doesn't the motive lie deeper than big pharma greed? Isn't the real monster the globalists of Davos? Big pharma has been an eager henchman for them.
“After about 2 hours, the… kitten became comatose, started salivation and died after 1/2 hour”
“The presented kitten also started salivating about 2 hours of the ivermectin administration, developed ataxia but retained some conscousness and rightening response. The next morning it was found comatose. Examination… revealed mild salivation, mydriasis, coma, slight fever (102.4F), and an accelerated respiration rate. Severe tachycardia, the heart rate being almost uncountable. It died 12 hours [later]”
“All animals became withdrawn 48 hours after IVM administration. All treated animals recorded clinical manifestations including rashes, itching, diarrhoea, conjunctival haemorrhages, lymphnode enlargement, pinkish ears, swollen face and restlessness; one animal died 5 hours after IVM administration.”
“Macroscopic changes in post-mortem tissues observed comprised haemorrhages in the brain, lungs, heart, which seen in all groups given ivermectin but not in the untreated animals.”
“The number of mf seen in the brain and kidneys of animals administered IVM alone tripled that of control animals. Co-administration of IVM+PSE caused a greater increase in mf in the brain and kidneys”
“Bab 08 (with an initial Loa mf load of 124,700 mf/mL) became unbearably restless, lost appetite and died 5 hours after treatment.”
“The outcome of interest was cases of severe neurotoxicity (SN) in adult/adolescent patients (>11 years) treated with ivermectin.”
“6 cases and 11 cases series reports in patients treated for strongyloidiasis, onchocerciasis, loiasis and scabies infections reported SN occurrence such as consciousness disorders, seizure or convulsion, encephalopathy and coma. SN [severe neurotoxicity] not only was associated with Onchocerciasis treatment in Loa loa coinfected patients.”
“Chandler RE reported 28 SN [severe neurotoxicity] cases after ivermectin use outside the Onchocerciasis indication and Nzolo D et al reported cases of SN [severe neurotoxicity] even with low blood levels of Loa loa microfilari”
“2 studies associated SN [severe neurotoxicity] with the presence of ABCB1 mutation. Baudou E et al reported the case of patient with two human ABCB1 mutations who suffered SN and Bourguinat C et al showed homozygotic haplotypes associated with alterations in drug disposition in 2 cases.”
“SN [severe neurotoxicity] after ivermectin use must be detected early to avoid fatal consequences. Authors related this toxicity with human ABCB1 nonsense mutations that allow ivermectin penetration into the central nervous system. This could be a future field of research”
Nursing Home Horrified When 32% Of Seniors Treated With Ivermectin For Scabies Died
“On Nov 10, 1995, all residents were treated with a single oral dose of ivermectin (150–200 μg/kg of body weight)… Over the succeeding 6 months, there was a pattern of excess deaths among the 47 residents who had received ivermectin. We retrospectively constructed a 47-patient cohort of those who had not had scabies for comparison purposes… we deliberately maximised the number of deaths in the comparison [control] group. Between Nov 10, 1995, and May 10, 1996, 15 of the 47 who had received ivermectin died, compared with five of the age-matched and sex-matched cohort.”
“Those in the ivermectin group developed a sudden change in behaviour with lethargy, anorexia, and listlessness which preceded death”
To HENDY who has loaded the comments of this piece with anti-Ivermectin studies, we have sent your links to medical experts who are reviewing them and we will reply after the examination is complete.
You have provided an excessive amount of medical documentation so it is going to take us some time to respond.
Hi Michael, these are not "anti-ivermectin" studies. That's a childish way to frame it. These are actually just a few of the studies. I can't even keep track of them myself. I can keep sending more and more if you like but I think you get the point.
I've taken IVM myself and did a curiosity search and started to see extremely alarming results in these studies. Needless to say, I don't take it anymore.
I definitely believe your concerns are valid and need to be looked into.
There are many studies where the IVM dosage was doubled, tripled and MORE - and then the conclude "Oh! it's unsafe!" - well, of course it's unsafe at unsafe levels.
Many of the studies you are referencing are in animals - which is odd at this point because for decades BILLIONS of humans have taken it, so we should really stay focused on results in humans as there is plenty to look at.
And, of course, Big Pharma has a MOTIVE to fund studies that discredit this drug because it is cheap and has no patent on it.
Nevertheless, I have sent your concerns to medical doctors we work with and await their responses. It's worthy of inquiry, for sure.
I agree about the financial incentives of big pharma and off-patent drugs.
The Nigerian fertility study was never followed up properly, and that's a huge red flag to me.
Ivermectin was supposed to be a river blindness cure but seeing people and animals go blind from IVM is extremely concerning.
In a paper called ‘Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations’ a case study is examined by which a 13 year old boy was sent to the hospital in a coma after just one ivermectin pill.
https://www.nejm.org/doi/10.1056/NEJMc1917344?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Retinopathy associated with ivermectin toxicosis in five cats’
--
“Five domestic shorthair farm cats … sudden onset of tremors, obtundation, blindness, and dilated pupils. Less than 12 hours earlier, the owner had attempted to treat the cats for a suspected ear mite (Otodectes cynotis) infestation by aural administration of a dose of an ivermectin paste intended for oral administration to horses (approx 22 mg/cat; half of the dose was administered into each ear canal).”
--
https://sci-hub.se/https://doi.org/10.2460/javma.246.11.1238
Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases,’ researcher Twum-Danso goes through passive reported serious adverse events for Ivermectin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147655/
“For more than half of the cases (n = 118; 57%), the SAE occurred following their first exposure to ivermectin. The mean time from ivermectin treatment to onset of symptoms was 2.2 days (95% CI: 1.8, 2.5)”
Of the cases with altered mental status when first encountered by a clinician (n = 106), 52 were confused, obtunded or lethargic while 16 presented with stupor and 38 presented in frank coma.
“In this study, the values of sperm motility and concentration were observed to decrease significantly (p<0.01) when compared with the control group.”
https://journals.tubitak.gov.tr/veterinary/vol26/iss2/26/
In a study called ‘Effect of ivermectin on male fertility and its interaction with P-glycoprotein inhibitor (verapamil) in rats’ by El-Nahas & El-Ashmawy
https://pubmed.ncbi.nlm.nih.gov/21783912/
“We observed significant reduction in the sperm counts and sperm motility of the patients tested. On the morphology there was significant increase in the number of abnormal sperm cells. This took the forms of two heads, double tails, white (albino) sperms and extraordinarily large heads. It is suspected that the above alterations in the already determined parameters of the patients’ sperm cells could only have occurred as a result of their treatment with ivermectin.”
https://www.scholarsresearchlibrary.com/articles/effects-of-ivermectin-therapy-on-the-sperm-functions-of-nigerian-onchocerciasis-patients.pdf
Ivermectin was touted as a perfectly safe drug, and now we see all the studies that it causes infertility and a long list of alarming health problems including blindness and paralysis.
Where are "all the studies" you refer to with no citation?
Ivermectin has been used for decades, taken by BILLIONS of people and won the Nobel Prize for ending 2 endemic disease in humans. Please post references to the "long list of alarming health problems" you claim it is connected to
I don't think I can post links in the comments here. I think it would get flagged as spam. If you want the full download, I can start popping it in here.
I thought it was super safe and very effective and this does not appear to be the case.
Yes you certainly can post links in the comments. I do it all the time on Substack.
Full disclosure - I and my family have taken Ivermectin multiple times and it has worked very well, safe and effective, every time. I am open to reviewing documentation.
Post the links.
1. “Effects of ivermectin on spermatocyte chromosomes: Structural aberrations: Cytological analysis of diakinesis-metaphase I spermatocytes of the treated samples revealed significant increase in chromosome aberrations over the control values.”
“Analysis of the treated samples revealed significant increase in meiotic aberrations, 33.83% vs 5.8% for the control (P < 0.001)… These findings supports the mutagenicity of IVM”
https://www.researchgate.net/publication/331770189_The_mutagenic_effects_of_ivermectin_in_germinal_cells_and_serum_protein_of_the_mouse
2. “In addition, the numbers of binucleated lymphocytes showed dose dependent decrease than control. These results revealed that the drug has a cytotoxic effect on the number of cell divisions. As the micronuclei are small chromatin-containing bodies arising from chromosome fragmentation by breaks or deletion, the results of MN [micronuclei] formation confirmed our results of chromosomal aberrations indicating the clastogenic effects of ivermectin.”
https://ejhm.journals.ekb.eg/article_17657_c015825d82c285db1eaf1ae0be627bf6.pdf
3. “IVM induced high level of chromosome aberrations in somatic cells, as it is ascertained by chromosome aberration assay and micronuclei production in bone marrow cells. This study revealed high clastogenic and genotoxic potential of IVM on mice”
https://www.iosrjournals.org/iosr-jestft/papers/vol9-issue2/Version-3/D09231729.pdf
4. “… IVM and ivomec® … induced DNA-strand breaks revealed by SCGE [single cell gel electrophoresis]”
“Both chemicals induced DNA-strand breaks revealed by the comet assay”
“IVM and ivomec® exert both genotoxicity and cytotoxicity in mammalian cells in vitro, at least in CHO K1 cells.”
“A brief 80 min pulse-treatment of 5.0–50.0 μg/ml of IVM or 25.0 and 50.0 μg/ml of ivomec® , resulted in a manifest level of single DNA-strand break induction.” https://www.sciencedirect.com/science/article/abs/pii/S0304389408016178?via%3Dihub
5. “The results indicate that IVM can induce DNA double-strand breaks in HeLa cells, and the degree of double-strand break is dependent on the concentration of IVM.”
“Ivermectin has significant ability to induce DNA oxidative damage and enhance autophagy in HeLa cells”
“As expected, we found that IVM can induce oxidative double-stranded damage in HeLa cells, indicating that IVM has potential genotoxicity to human health.”
“We conclude that IVM produces genotoxicity and cytotoxicity by inducing DNA damage and AMPK/mTOR-mediated autophagy, thereby posing a potential risk to human health.”
https://www.sciencedirect.com/science/article/abs/pii/S0045653520316428
6. “The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations”
“It was observed a dose-dependence in the frequency of MN [Micronuclei] in T. pallida considering the highest concentrations (11.42, 22.84 and 45.68 × 10−5 mM) differing statistically (p ≤ 0.05) from the negative control, evidencing a genotoxic effect of IVM”
“The results observed in D. melanogaster and T. pallida showed that IVM can increase the damage in the genetic material, leading to genetic instability.”
“Findings showed an increase in the frequency of micronuclei in T. pallida treated with 11.42, 22.84 and 45.68 x 10 −5 mM of IVM. We conclude that chronic exposure to IVM is directly associated with events resulting from genetic instability (genotoxicity and carcinogenicity).”
https://europepmc.org/article/med/31152944
7. “IVM… induced DNA-strand breaks enhancing both slightly damaged and damaged cells at 25–50 μg/ml IVM”
“Data indicated that IVM exerts both genotoxicity and cytotoxicity in insect cells [A. albopictus larvae CCL-126 cells] in vitro”
https://www.tandfonline.com/doi/abs/10.1080/02772241003625284?journalCode=gtec20
Hi Michael,
She definitely posted them, and I can’t wait to hear your response! I quickly reviewed them, and I’m concerned by what I read. However, I don’t fully understand what I read, so hopefully your response will help me understand. As I said, it was a quick review, and I know with anything too much of even a “good thing” can be harmful and or deadly, and too little can also be problematic. So comparing the dosage of Ivermectin given to the mice compared to humans is something that I wasn’t able to determine because I don’t have the scientific training. Also, what were the health of the mice in the studies? How long had these mice lived caged in a stressful environment? Were they given a complete bill of health prior to the experiment? I hope you can clarify that for me. Also, I always want to know about who conducted the study, and were there any conflicts of interest such as any profit motives, fear motives, and job security motives? Clearly, Hendy was well prepared for your request for information. I hope your response will be able to either validate her information or discredit it . Either way, I just want the truth because my family and I have been using it to recover from illnesses, vaccine injuries, and to maintain health. Thanks 🙏 Michael
We have medical professionals taking a look at the studies referenced.
I have personally taken Ivermectin numerous times as have my parents who are both over 70 years of age. It worked remarkably when we had COVID. We supported it with an intense supplementation protocol as well.
My mother is extremely sensitive to all medicines and she had no negative reaction to it, only positive.
None of this is meant as medical advice, I am not a doctor.
My overall understanding of the literature is that there are very minimal risks to taking Ivermectin. But we are having medical professionals review what's been posted here and we will respond. The earliest we will be able to respond is sometime next week.
Hi Michael,
Like your mother, I’m extremely sensitive to drugs, and I’ve had many bad experiences from them including life threatening with Vioxx and an Ace Inhibitor. I got Ivermectin early on, and I used it prophylactically as well as when I finally did get Covid. The only reaction I had was with my eyes. It was actually an amazing experience. I had injured my eyes from playing a game online that had flashing magenta colored gems that would pop on the screen. After playing it for a couple of weeks, I started seeing flashing lights, and I thought I was having a stroke. But I wasn’t having a stroke, so I went to an eye doctor who said that my retinas weren’t detaching. But no solutions were given for the debilitating flashing lights that prevented me from being able to drive at sunset or nighttime. It was very stressful because it was constant even in my home at sunset and nighttime, and it went on for months until I took Ivermectin. The first thing I noticed was that my eyes hurt, but I didn’t panic because I knew that it prevented River Blindness. So I just assumed that it was helping my eyes.
After the first time I used Ivermectin, the flashing in my right eye disappeared!! I was amazed and so happy!! Then the second time I used it, the left eye hurt, and then the flashing lights were gone. So for me, Ivermectin helped my eyes and eliminated a very debilitating condition which I was so grateful for!! So I’m a huge fan of Ivermectin; but regardless of my support for it, we need the facts and the truth. So I’m glad to know that you are having medical professionals reviewing the studies, and I look forward to hearing what they have to say when that time comes. Thank you 🙏 Michael for your response and your efforts in finding the truth. Bambi
Nice.
But doesn't the motive lie deeper than big pharma greed? Isn't the real monster the globalists of Davos? Big pharma has been an eager henchman for them.
How so?
“After about 2 hours, the… kitten became comatose, started salivation and died after 1/2 hour”
“The presented kitten also started salivating about 2 hours of the ivermectin administration, developed ataxia but retained some conscousness and rightening response. The next morning it was found comatose. Examination… revealed mild salivation, mydriasis, coma, slight fever (102.4F), and an accelerated respiration rate. Severe tachycardia, the heart rate being almost uncountable. It died 12 hours [later]”
https://pubmed.ncbi.nlm.nih.gov/14748414/
“All animals became withdrawn 48 hours after IVM administration. All treated animals recorded clinical manifestations including rashes, itching, diarrhoea, conjunctival haemorrhages, lymphnode enlargement, pinkish ears, swollen face and restlessness; one animal died 5 hours after IVM administration.”
“Macroscopic changes in post-mortem tissues observed comprised haemorrhages in the brain, lungs, heart, which seen in all groups given ivermectin but not in the untreated animals.”
“The number of mf seen in the brain and kidneys of animals administered IVM alone tripled that of control animals. Co-administration of IVM+PSE caused a greater increase in mf in the brain and kidneys”
“Bab 08 (with an initial Loa mf load of 124,700 mf/mL) became unbearably restless, lost appetite and died 5 hours after treatment.”
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005576
“The outcome of interest was cases of severe neurotoxicity (SN) in adult/adolescent patients (>11 years) treated with ivermectin.”
“6 cases and 11 cases series reports in patients treated for strongyloidiasis, onchocerciasis, loiasis and scabies infections reported SN occurrence such as consciousness disorders, seizure or convulsion, encephalopathy and coma. SN [severe neurotoxicity] not only was associated with Onchocerciasis treatment in Loa loa coinfected patients.”
“Chandler RE reported 28 SN [severe neurotoxicity] cases after ivermectin use outside the Onchocerciasis indication and Nzolo D et al reported cases of SN [severe neurotoxicity] even with low blood levels of Loa loa microfilari”
“2 studies associated SN [severe neurotoxicity] with the presence of ABCB1 mutation. Baudou E et al reported the case of patient with two human ABCB1 mutations who suffered SN and Bourguinat C et al showed homozygotic haplotypes associated with alterations in drug disposition in 2 cases.”
“SN [severe neurotoxicity] after ivermectin use must be detected early to avoid fatal consequences. Authors related this toxicity with human ABCB1 nonsense mutations that allow ivermectin penetration into the central nervous system. This could be a future field of research”
https://ejhp.bmj.com/content/29/Suppl_1/A167.2
Nursing Home Horrified When 32% Of Seniors Treated With Ivermectin For Scabies Died
“On Nov 10, 1995, all residents were treated with a single oral dose of ivermectin (150–200 μg/kg of body weight)… Over the succeeding 6 months, there was a pattern of excess deaths among the 47 residents who had received ivermectin. We retrospectively constructed a 47-patient cohort of those who had not had scabies for comparison purposes… we deliberately maximised the number of deaths in the comparison [control] group. Between Nov 10, 1995, and May 10, 1996, 15 of the 47 who had received ivermectin died, compared with five of the age-matched and sex-matched cohort.”
“Those in the ivermectin group developed a sudden change in behaviour with lethargy, anorexia, and listlessness which preceded death”
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)63020-6/abstract